Automated cell counter
& cell viability analyzer


High throughput at µl scale designed for cell count of small scale parallel bioreactors

For research use only (RUO). Not for use in diagnostic procedures.

Sample Icon

Sample preparation free

Short Time

Short time results

High Repet

High repeatability

Low Volume

Low sample volume

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Match with reference trypan blue method


The NORMA 4S, based on the new lens-less technology, is a fully automatic cell counter for high throughput cell culture monitoring. It rapidly measures cell concentration and viability without repeatability compromise. The NORMA 4S provides an unmatched accuracy and precision thanks to its wide fields of view (29.4 mm2) that allows counting several thousands of cells within a single sample image! No need to adjust focus, brightness or any other parameters, our algorithm will reconstruct cells wherever cells are located… from a few micrometres to some millimetres! There is no sample preparation: no dilution and no Trypan Blue! You just have to take about 3µL of your sample and to deposit it on the measuring slide. The NORMA 4S is ready for receiving the sample from the robotic arms of a parallel micro bioreactor, an automatic sampler or even a pipette.

NORMA 4S pipette automation


  • Automatic cell count and viability
  • Sample preparation free
  • Short time results
  • High repeatability
  • Low sample volume
  • Match with reference Trypan Blue method
check norma

Automatic cell count


Cell size distribution

Ratio aspects

Growth curves

Ready for seamless integration in high-throughput automated micro bioreactors

The NORMA 4S is composed of a refillable cartridge of 36 4-chambers slides allowing 144 samples to be made. A slide from the cartridge is automatically put on the sample area where the sample can be drop and start the measurement. When it’s done, the slide is thrown in the trash and a new one is ready to receive four another samples. The technology directly acquires the light diffraction properties of each individual cells through their hologram images without any objectives, lens of focus settings. Living and dead cells have significant holographic patterns that can be distinguished and accurately counted. The measurements are analysed by the HORUS software.

Horus Software for cell viability analyzer NORMA
NORMA 4S Exploded View with number

The NORMA 4S works with precise calibrated measurement chambers (1) constructed on single-use slides (2). The refillable slide cartridge (3) is ready to run 144 samples (4) without user interaction.

Norma4S and Ambr15 SARTORIUS

The integration of the NORMA 4s into the Ambr15

The NORMA 4S is fully adapted to the Sartorius Ambr15 automated micro bioreactor.

Iprasense Horus Software Cell Culture Monitoring and your Cell Viability

HORUS Software Included

Our best software for cell counting and cell analysis !

HORUS Software is included with the acquisition of our products and is regularly updated by our development team.

Technical specifications

Cells Mammalian cells: CHO - JURKAT - HEK293 - YT - NIH3T3 - PC12 - HELA - VERO
Insect cells: SF9 - HIGHFIVE
Concentration range 10⁴-4.10⁷ cell/ml
Cell size range 7 - 50 μm
Sample volume 3 - 13 μl
Numbers of sample 4 samples/slide - 144 samples/box
Viability determination Light diffraction
Counting time 15 seconds
Image .PNG / .BMP / .TIFF / .RAW / .AVI
Dimensions 30 x 11,5 x 25 cm
Enclosure Stainless steel, POM
Weight 4 kg
Power supply USB + 24 V DC (110 - 240 V AC)
Pharmaceutical industries 21 CFR part 11 & IQ/OQ
Integration Ambr15®

Accessories and consumables

HORUS Software
Laptop computer
NORMA 4S Cell counting slides – 4 chambers: 20 µm (from 2.1 x10^6 to 5.1x10^7 cells/ml)
NORMA 4S Cell counting slides – 4 chambers: 100 µm (from 10^4 to 5.1x10^6 cells/ml)


The NORMA 4S is an innovative automated cell counter and cell viability analyzer designed for precise and accurate cell counting, offering unmatched convenience and reliability.

The NORMA 4S boasts several key features:

    • Automatic cell count and viability analysis
    • Small device footprint
    • Sample preparation-free operation
    • Rapid results within a short time frame
    • High repeatability for consistent performance
    • Low sample volume requirement
    • Compatibility with the Trypan Blue method for reference matching

The NORMA 4S utilizes state-of-the-art lens-less technology to rapidly measure cell concentration and viability without compromising accuracy. Its wide field of view enables the counting of several thousand cells within a single sample image. With no need for adjustments, such as focus or brightness, users can simply deposit their sample onto the measuring slide, making it exceptionally user-friendly.

The NORMA 4S directly acquires the light diffraction properties of individual cells through hologram images, enabling precise cell segmentation. The results, generated by the accompanying HORUS software, provide detailed insights into cell viability, size distribution, aspect ratios, and growth curves, presented in a user-friendly graphical interface.

Using the NORMA 4S is effortless:

    1. Extract your unprepared sample using the provided pipette (label-free, undiluted).
    2. Load the sample into the slide chamber.
    3. Insert the slide into the NORMA 4S and press measure.

Yes, comparative studies have demonstrated a strong correlation between the NORMA 4S and traditional Trypan Blue methods, affirming its reliability and repeatability.

Absolutely, the HORUS software, our premier cell counting and analysis software, is included with every NORMA 4S purchase. It is regularly updated by our dedicated development team to ensure optimal performance.

Yes, all our products are 21 CFR.

The NORMA range allows you to count your cells and determine their viability and diameter. You will get automatically saved images.

No, only your raw sample is needed in order to do the cell count and viability analysis.

Yes, all our products are driven directly by our HORUS software. The data is also analysed by it.