Automated cell counter
& cell viability analyzer
NORMA 4S
High throughput at µl scale designed for cell count of small scale parallel bioreactors
For research use only (RUO). Not for use in diagnostic procedures.
Sample preparation free
Short time results
High repeatability
Low sample volume
Match with reference trypan blue method
100% Automatic Solutions
on your Parallel Micro Bioreactors
The NORMA 4S, based on the new lens-less technology, is a fully automatic cell counter for high throughput cell culture monitoring. It rapidly measures cell concentration and viability without repeatability compromise. The NORMA 4S provides an unmatched accuracy and precision thanks to its wide fields of view (29.4 mm2) that allows counting several thousands of cells within a single sample image! No need to adjust focus, brightness or any other parameters, our algorithm will reconstruct cells wherever cells are located… from a few micrometres to some millimetres! There is no sample preparation: no dilution and no Trypan Blue! You just have to take about 3µL of your sample and to deposit it on the measuring slide. The NORMA 4S is ready for receiving the sample from the robotic arms of a parallel micro bioreactor, an automatic sampler or even a pipette.
Features of our Cell Counter & Cell Viability Analyzer
- Tiny device
- In direct from your incubator
- Time-Lapse & Movie
- Many cell cultures application
- Robust
- High Contrast
- Always in focus
- Wide field of view
Automatic cell count
Viability
Cell size distribution
Ratio aspects
Growth curves
Accessories & Consumables of our Cell Counter & Cell Viability Analyzer
- HORUS Software
- Laptop Computer
- NORMA 4S Cell counting slides
4 chambers : 20 µm
(from 2.1 x10^6 to 5.1×10^7 cells/ml) - NORMA 4S Cell counting slides
4 chambers : 100 µm
(from 10^4 to 5.1×10^6 cells/ml)
Ready for seamless integration in
high-throughput automated micro bioreactors
The NORMA 4S is composed of a refillable cartridge of 36 4-chambers slides allowing 144 samples to be made. A slide from the cartridge is automatically put on the sample area where the sample can be drop and start the measurement. When it’s done, the slide is thrown in the trash and a new one is ready to receive four another samples. The technology directly acquires the light diffraction properties of each individual cells through their hologram images without any objectives, lens of focus settings. Living and dead cells have significant holographic patterns that can be distinguished and accurately counted. The measurements are analysed by the HORUS software.
The NORMA 4S works with precise calibrated measurement chambers (1) constructed on single-use slides (2). The refillable slide cartridge (3) is ready to run 144 samples (4) without user interaction.
The integration of the NORMA 4S
into the Ambr15
The NORMA 4S is fully adapted to the Sartorius Ambr15 automated micro bioreactor.
HORUS Software for our Live Cell Imaging System Included
Our best software for cell counting and cell analysis !
HORUS Software is included with the acquisition of our products and is regularly updated by our development team.
Technical Specifications
of our Cell Counter & Cell Viability Analyzer
- Mammalian cells : CHO – JURKAT – HEK293 – YT – NIH3T3 – PC12 – HELA – VERO
- Insect cells : SF9 – HIGHFIVE
10⁴-4.10⁷ cell/ml
7 – 50 μm
3 – 13 μl
4 samples/slide – 144 samples/box
Light diffractation
15 seconds
- .PNG
- .BMP
- .TIFF
- .RAW
- .AVI
- Stainless steel
- POM
30 x 11,5 x 25 cm
4 kg
USB + 24 V DC (110 – 240 V AC)
- 21 CFR part 11
- IQ/OQ
SARTORIUS Ambr15®
F.A.Q.
The NORMA 4S is an innovative automated cell counter and cell viability analyzer designed for precise and accurate cell counting, offering unmatched convenience and reliability.
The NORMA 4S boasts several key features:
- Automatic cell count and viability analysis
- Small device footprint
- Sample preparation-free operation
- Rapid results within a short time frame
- High repeatability for consistent performance
- Low sample volume requirement
- Compatibility with the Trypan Blue method for reference matching
The NORMA 4S utilizes state-of-the-art lens-less technology to rapidly measure cell concentration and viability without compromising accuracy. Its wide field of view enables the counting of several thousand cells within a single sample image. With no need for adjustments, such as focus or brightness, users can simply deposit their sample onto the measuring slide, making it exceptionally user-friendly.
The NORMA 4S directly acquires the light diffraction properties of individual cells through hologram images, enabling precise cell segmentation. The results, generated by the accompanying HORUS software, provide detailed insights into cell viability, size distribution, aspect ratios, and growth curves, presented in a user-friendly graphical interface.
Using the NORMA 4S is effortless:
- Extract your unprepared sample using the provided pipette (label-free, undiluted).
- Load the sample into the slide chamber.
- Insert the slide into the NORMA 4S and press measure.
Yes, comparative studies have demonstrated a strong correlation between the NORMA 4S and traditional Trypan Blue methods, affirming its reliability and repeatability.
Absolutely, the HORUS software, our premier cell counting and analysis software, is included with every NORMA 4S purchase. It is regularly updated by our dedicated development team to ensure optimal performance.
Yes, all our products are 21 CFR.
The NORMA range allows you to count your cells and determine their viability and diameter. You will get automatically saved images.
No, only your raw sample is needed in order to do the cell count and viability analysis.
Yes, all our products are driven directly by our HORUS software. The data is also analysed by it.