AUTOMATIC CELL COUNTER AND CELL VIABILITY ANALYZER

NORMA 4S

High throughput at µl scale designed for cell count of small scale parallel bioreactors

For research use only (RUO). Not for use in diagnostic procedures.

NORMA 4S CELL ANALYSIS CELL COMPTING CELL VIABILITY
Sample Icon

SAMPLE PREPARATION FREE

Short Time

SHORT TIME RESULTS

High Repet

HIGH REPEATABILITY

Low Volume

LOW SAMPLE VOLUME

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MATCH WITH REFERENCE TRYPAN BLUE METHOD

100% AUTOMATIC SOLUTIONS ON YOUR PARALLEL MICRO BIOREACTORS

The NORMA 4S, based on the new lens-less technology, is a fully automatic cell counter for high throughput cell culture monitoring. It rapidly measures cell concentration and viability without repeatability compromise. The NORMA 4S provides an unmatched accuracy and precision thanks to its wide fields of view (29.4 mm2) that allows counting several thousands of cells within a single sample image! No need to adjust focus, brightness or any other parameters, our algorithm will reconstruct cells wherever cells are located… from a few micrometres to some millimetres! There is no sample preparation: no dilution and no Trypan Blue! You just have to take about 3µL of your sample and to deposit it on the measuring slide. The NORMA 4S is ready for receiving the sample from the robotic arms of a parallel micro bioreactor, an automatic sampler or even a pipette.

NORMA 4S pipette automation

FEATURES OF THE NORMA4S

  • Automatic cell count and viability
  • Small device
  • Sample preparation free
  • Short time results
  • High repeatability
  • Low sample volume
  • Match with reference Trypan Blue method
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AUTOMATIC CELL COUNT

VIABILITY

CELL SIZE DISTRIBUTION

RATIO ASPECTS

GROWTH CURVES

READY FOR SEAMLESS INTEGRATION IN HIGH-THROUGHPUT AUTOMATED MICRO BIOREACTORS

The NORMA 4S is composed of a refillable cartridge of 36 4-chambers slides allowing 144 samples to be made. A slide from the cartridge is automatically put on the sample area where the sample can be drop and start the measurement. When it’s done, the slide is thrown in the trash and a new one is ready to receive four another samples. The technology directly acquires the light diffraction properties of each individual cells through their hologram images without any objectives, lens of focus settings. Living and dead cells have significant holographic patterns that can be distinguished and accurately counted. The measurements are analysed by the HORUS software.

Horus Software for cell viability analyzer NORMA
NORMA 4S Exploded View with number

The NORMA 4S works with precise calibrated measurement chambers (1) constructed on single-use slides (2). The refillable slide cartridge (3) is ready to run 144 samples (4) without user interaction.

Norma4S and Ambr15 SARTORIUS

THE INTEGRATION OF THE NORMA 4S INTO THE AMBR15

The NORMA 4S is fully adapted to the Sartorius Ambr15 automated micro bioreactor.

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Iprasense Horus Software Cell Culture Monitoring and your Cell Viability

HORUS Software Included

Our best software for cell counting and cell analysis !

HORUS Software is included with the acquisition of our products and is regularly updated by our development team.

TECHNICAL SPECIFICATIONS

Cells
Eucaryotic cells: adherent monolayer, suspension cell at bottom of culture ware or in micro-slides, 3D sheroids
Media
Liquid or semi-liquid (collagen)
Culture contains
Standard plastic petric dishes, culture flasks, multiwell plates, max height 55 mm
Resolution
1 micron
Field of view
29.4 mm²
Working distance
0 to 5 mm
Image rate
1.5 image/min
Light source
LED
Sensor
CMOS 10 Mpixels
Weight
1 kg
Dimensions
12 * 11 * 10 cm
Power supply
USB

ACCESSORIES AND CONSUMABLES

HORUS Software
21 CFR
Scratch Assay analysis module for HORUS Software
Cell Tracking analysis module for HORUS Software
Cell Tube Formation analysis module for HORUS Software
Cytonote cable – 2 meters
Laptop computer
IQ/OQ

F.A.Q.

The NORMA range allows you to count your cells and determine their viability and diameter. You will get automatically saved images.

No, only your raw sample is needed in order to do the cell count and viability analysis.

Yes, all our products are driven directly by our HORUS software. The data is also analysed by it.

Yes, all our products are 21 CFR.

By default, the image format is JPEG. It is possible to have images in PNG, BITMAP, TIFF. The results can be exported in CSV, XML, XLSX format.