Live Cell Imaging inside the Incubator


Time-lapse images of cells and real time analysis from inside your incubator

A small footprint device that stays always in focus with Petri dishes, T-flasks, slides or microfluidic chips

For research use only (RUO). Not for use in diagnostic procedures.

Cytonoye 1W Live cell imaging

CYTONOTE implements our patented Lensless Technology in a tiny device design to fit within any incubator. 
The small foot print (132 cm² only!) allows you to follow any of your cell culture without any incubator adaptation or working space limitation.


Label free & high contrast

No Zoom

Always in focus

No Settings

Settings free


Huge field of view


Cell proliferation

Cell proliferation through cell count and quantitative confluence determination



The very wide area allows to observe the full angiogenesis process with high level of details


Cell migration

Chemotaxis, wound healing on high statistical number of cells and very wide area

Time-lapse images of cells and real time analysis from inside your incubator

The CYTONOTE 1W uses our patented lens-less imaging technology in a tiny device to fit with any incubator. The CYTONOTE 1W is the simplest live cell-imaging system designed for recording cell movies and analyzing a variety of cell culture from the incubator. The innovative and patented “Lens-less imaging” technology pushes the boundaries of microscopy with its super wide field of view and its capability to capture and analyze precisely several thousands of cells without any focus and brightness settings. This technology simplifies the Live Cell Imaging technique and transforms the complex and expensive microscope method into a cost-effective solution.


  • Tiny device
  • In direct from your incubator
  • Time-Lapse & Movie
  • Many cell cultures application
  • Robust
  • High Contrast
  • Always in focus
  • Wide field of view


  • Real-Time Imaging of your cell culture
  • Time-Lapses and Movies of your cells
  • Confluence analysis
  • Growth curves
  • Migration test
  • Proliferation test
  • Cell morphology
  • Cell population
  • Cell attachment / detachment
  • Cell tracking

How to use our cell imager analyser?

The CYTONOTE 1W is designed to be compatible with every standard lab dishes, T-flask or slides. Select your container and place it on the CYTONOTE 1W. The acquisition time between two measurements is 20 minutes by default, but you can change this time if you wish. By performing acquisitions over a give period of time you will be able to obtain time lapses and movies of your cells.

As explained, no need to adjust focus, brightness or any other parameters, our algorithm will reconstruct cells wherever cells are located… from few micrometers to some millimeters! This characteristic makes the CYTONOTE 1W an extremely robust device not fearing temperature variation, cells descent inside Matrigel, or any other parameter which can affect traditional focus adjustment.

What are the results ?

The CYTONOTE 1W works on an ultra-wide field of view, where all data recovered from picture represent your cell culture.

The image analysis and the result from the CYTONOTE 1W are performed from the HORUS dedicated Software. HORUS is application oriented: it provides quantitative confluence determination, cell size, cell tracking… Full field image (30mm2) of the sample is stored and can be accessed and zoomed at any time.


The simultaneously option

The HORUS Software has been designed to connect up to 6 CYTONOTE 1W simultaneously allowing the control of up to 6 independent parallel cell cultures.

Iprasense Horus Software Cell Culture Monitoring and your Cell Viability

HORUS Software Included

Our best software for cell counting and cell analysis !

HORUS Software is included with the acquisition of our products and is regularly updated by our development team.


“What I like most about the CYTONOTE is the tracking of thousands of cells. With the microscope, you can only follow a few hundred cells… If I could not track so many cells, I would never have been able to see this new cell rhythm. This allows the discovery of new phenomena that cannot be seen with other microscopes, and this without labelling or preparation and in direct from the incubator.The 6-well system is excellent for parallel culture monitoring, especially when testing with drugs! It’s very convenient!It’s a tool that is now part of our protocols! It’s essential to have several instruments to obtain all types of information. The CYTONOTE allows to bring a lot of additional information that is not possible to get with other microscopes.”
CEA - 2021

Technical specifications

Cells Eucaryotic cells : Adherent monolayer, Suspension cell at bottom of culture ware or in micro-slides, 3D spheroids
Media Liquid or Semi-solid (collagen)
Culture Vessels Standard plastic petri dish, culture flask, multiwell plate, max height 55mm
Resolution 1 micron
Field of view 30 mm² (6,5 mm x 6,5 mm)
Working distance 0 to 5 mm
Image rate 1,5 image/min
Light source LED
Sensor CMOS 10 Mpix
Image .JPEG / .PNG / .BITMAP / .TIFF
Enclosure Stainless Steel
Dimensions 12 x 11 x 10 cm
Weight 1 kg
Power Supply USB
Pharmaceutical industries 21 CFR part 11 & IQ/OQ

Accessories and consumables

HORUS Software
21 CFR part 11
Scratch Assay analysis module for HORUS Software
Cell Tracking analysis module for HORUS Software
Cell Tube Formation analysis module for HORUS Software
Cytonote cable – 2 meters
Laptop computer


A Live Cell Imaging System is a cutting-edge technology that allows researchers to observe and analyze living cells in real-time within their natural environment, such as inside an incubator.

The CYTONOTE system offers high contrast, always-in-focus images, settings-free operation, a huge field of view, and robust performance.

With its patented lens-less imaging technology, the CYTONOTE eliminates the need for manual adjustments like focus and brightness settings. It provides hassle-free monitoring of up to 6 cell cultures in parallel.

The CYTONOTE system enables real-time imaging of cell cultures, time-lapses, confluence analysis, growth curves, migration and proliferation tests, cell morphology studies, cell tracking, and more.

Simply place your cell culture container, such as a Petri dish or T-flask, onto the CYTONOTE 1W. The system operates with a default acquisition time of 20 minutes between measurements, which can be adjusted as needed.

The CYTONOTE provides ultra-wide field-of-view imaging, with data analyzed using the dedicated HORUS software. Results include quantitative confluence determination, cell size analysis, cell tracking, and more.

By this product technology, there is a wide field of view, no manual adjustment step and the results are obtained in seconds.

The CYTONOTE supports various cell types and media, offers a resolution of 1 micron, a field of view of 30 mm², and operates with a CMOS 10 Mpix sensor. It’s compact, lightweight, and compatible with standard culture vessels.

Yes, accessories include cables, software modules for analysis (such as Scratch Assay and Cell Tracking), and compliance options for pharmaceutical industries (like 21 CFR part 11 and IQ/OQ).

Yes, all our products are 21 CFR.