AUTOMATIC CELL COUNTER AND VIABILITY ANALYZER

NORMA 4S

High throughput at µl scale designed for cell count of small scale parallel bioreactors

NORMA 4S cut out
AUCUNE PRÉPARATION D’ÉCHANTILLON

SAMPLE PREPARATION
FREE

ShortTime-1

SHORT TIME
RESULTS

HighRepet

HIGH
REPEATABILITY

Low Volume

LOW SAMPLE
VOLUME

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MATCH WITH REFERENCE
TRYPAN BLUE METHOD

PRODUCT OVERVIEW – NORMA 4S

100% AUTOMATIC SOLUTIONS ON YOUR PARALLEL MICRO BIOREACTORS

The NORMA 4S, based on the new lens-less technology, is a fully automatic cell counter for high throughput cell culture monitoring. It rapidly measures cell concentration and viability without repeatability compromise. The NORMA 4S provides an unmatched accuracy and precision thanks to its wide fields of view (29.4 mm2) that allows counting several thousands of cells within a single sample image! No need to adjust focus, brightness or any other parameters, our algorithm will reconstruct cells wherever cells are located… from a few micrometres to some millimetres! There is no sample preparation: no dilution and no Trypan Blue! You just have to take about 3µL of your sample and to deposit it on the measuring slide. The NORMA 4S is ready for receiving the sample from the robotic arms of a parallel micro bioreactor, an automatic sampler or even a pipette.

NORMA 4S cut out
NORMA 4S pipette automation

FEATURES OF THE NORMA 4S

  • Automatic cell count and viability
  • Small device
  • Sample preparation free
  • Short time results
  • High repeatability
  • Low sample volume
  • Match with reference Trypan Blue method
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AUTOMATIC
CELL COUNT

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VIABILITY

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CELL SIZE
DISTRIBUTION

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RATIO
ASPECTS

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GROWTH
CURVES

READY FOR SEAMLESS INTEGRATION IN HIGH-THROUGHPUT AUTOMATED MICRO BIOREACTORS

The NORMA 4S is composed of a refillable cartridge of 36 4-chambers slides allowing 144 samples to be made. A slide from the cartridge is automatically put on the sample area where the sample can be drop and start the measurement. When it’s done, the slide is thrown in the trash and a new one is ready to receive four another samples. The technology directly acquires the light diffraction properties of each individual cells through their hologram images without any objectives, lens of focus settings. Living and dead cells have significant holographic patterns that can be distinguished and accurately counted. The measurements are analysed by the HORUS software.

HORUS SOFTWARE NORMA 4S
NORMA 4S Exploded View with number

The NORMA 4S works with precise calibrated measurement chambers (1) constructed on single-use slides (2). The refillable slide cartridge (3) is ready to run 144 samples (4) without user interaction.

Integration NORMA 4S Ambr15

THE INTEGRATION OF THE NORMA 4S INTO THE AMBR15

The NORMA 4S is fully adapted to the Sartorius Ambr15 automated micro bioreactor.

For more details, go to the “Applications” Tab!

TECHNICAL SPECIFICATIONS – NORMA 4S

Cells Mammalian Cells
Concentration Range 10^4 – 4.10^7 cell/ml
Sample Volume 3-13 µl
Cell Size Range 7-50 μm
Viability Determination Light Diffraction
Counting Time 15 seconds
Image Format .png
Enclosure Stainless steel, POM
Dimensions 30 x 11.5 x 25 cm
Weight 4 kg
Power Supply 24 V DC (110-240 V AC power converter included)

ACCESSORIES AND CONSUMABLES – NORMA 4S

CONSUMABLES ACCESSORIES
Cell counting slide 20µm – 4 Chambers (from 2x10e6cells/mL to 5x10e7cells/mL) Laptop Computer
Cell counting slide 100µm – 4 Chambers (from 10e4cells/mL to 5x10e6cells/mL) Remote control TCP/IC module for HORUS
Beads Control 1M1 IQ/OQ
Beads Control 1M10 21 CFR Part 11
Beads Control 8M1
Beads Control 8M10

APPLICATIONS – NORMA 4S

Products Iprasense

A fully Automatic Cell Counter for High Throughput Cell Culture Monitoring  

MEDIA – NORMA 4S